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The Houthis have reported that all casualties in Hodeida from a recent U.S.-UK assault were civilians and have vowed a \
⏲ 3:9 👁 335K
MEDICAL ANIMATION TRANSCRIPT: Drug metabolism is the chemical conversion of drugs into water soluble compounds that can be excreted by the body. Drug metabolism mainly takes place in the liver, while excretion mainly takes place in the kidneys. Following drug administration, drugs must pass through tightly packed cells, crossing cell membranes to reach their sites of action. Usually drugs are lipophilic or fat soluble compounds, and cell membranes are composed of phospholipids, so drugs are able to cross them. However, for excretion by the kidneys, it's necessary to convert drugs to water soluble or hydrophilic compounds. Drugs are usually administered orally or parenterally. Parenteral drugs bypass the digestive tract. Parental routes include injection, transdermal patches, lotions, inhalants, and suppositories. If injected, the drugs reach general circulation quickly and have an immediate effect. If taken orally, drugs must pass through the cells of the gastrointestinal tract. Drugs cross through cells of the GI tract and travel to the liver via the hepatic portal vein. The liver has a chance to metabolize some of the drug before it goes into general circulation, this is called the first pass effect. In the liver, drugs enter hepatic cells where a series of enzymes in smooth endoplasmic reticulum metabolize them. Drugs move through the phospholipid membrane of endoplasmic reticulum. Hepatic microsomal enzymes such as p450 convert drugs from lipophilic to hydrophilic compounds. Repeated use of certain drugs increases the amount of metabolic enzymes and increases drug metabolism. This is called enzyme induction. Conversely, certain drugs compete to bind to metabolic enzymes thereby decreasing drug metabolism. This is called enzyme inhibition. Once metabolized, these hydrophilic metabolites leave the cell ready for excretion by the kidney. A drug's duration and intensity of effect are largely determined by metabolic rate. Increased metabolic rate will decrease drug duration and intensity by facilitating excretion. Decreased metabolic rate increases drug duration and intensity. A few of the factors affecting metabolic rate are the first pass effect, liver disease such as cirrhosis, neonates in the elderly have decreased liver function, compromised blood flow to the liver will lower metabolic rate, variation in amount and type of hepatic enzymes, poor diet and nutrition can affect normal liver function, and higher circulating drug levels due to dosage or patient's weight take longer to metabolize. ♪ [music] ♪<br/>
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Sclera limbus and ocular routes drug administration anatomy of eye opthalmology from route 11
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Street Fighter V<br/>Arcade Mode<br/>CPU level: Hard (Hardest)<br/>Character: Rose<br/>V-Skill: 1 (Soul Fortune)<br/>V-Trigger: 1 (Soul Dimension)<br/>Route: Street Fighter 5<br/>Continues: 0<br/><br/>Timestamps:<br/>00:00 Character Selection<br/>00:30 Laura<br/>02:46 Karin<br/>05:48 Juri<br/>08:14 Ibuki<br/>10:32 Menat<br/>12:28 Bonus Stage<br/>13:37 Nash<br/>16:02 Falke<br/>19:55 G (Secret Fight)<br/>22:46 Balrog<br/>25:52 Sagat<br/>28:25 M. Bison (Final Boss)<br/>30:52 Ending
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In a remarkable turn of events, a 37-year-old pregnant woman travelling on a government-run KSRTC bus from Thrissur to Kozhikode gave birth to a baby Girl on board after experiencing labour pains. Thanks to the timely assistance of the transport staff, doctors, and local residents, the baby was delivered safely.<br/> <br/> <br/>#KeralaNews #ViralVideo #KSRTCBus #BirthOnBus #HeroicBusDriver #HospitalStaff #EmergencyDelivery #IncredibleBirth #BusBaby #KeralaWoman #AmalaHospital #HeartwarmingStory #MotherAndBaby #SafeDelivery #BusJourney<br/>~HT.99~PR.152~ED.155~
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A man is walking the entire UK coastline with his pet dog - a journey of 11,023 miles.<br/><br/>Martyn Green, 37, began his mammoth trek on March 8 - 83 days ago - and has since walked 696 miles to reach his current point in Gillingham, Essex.<br/><br/>Martyn started this endeavour after he suffered serious injuries in a violent street robbery.<br/><br/>In December 2021, Martyn was stabbed four times in Torquay, Devon, by two men who were meeting with him to buy cannabis.<br/><br/>The incident left him shaken up and he became isolated.<br/><br/>After two long years, Martyn decided he couldn't carry on like this and set himself the challenge to walk the entire UK coastline with his three-year-old Collie mix, Rolo.
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Toni Kroos shared a touching moment with Real Madrid fans as he enjoyed a fairytale end to his club career by winning the Champions League at Wembley. <br/><br/>The German played his 718th and final club match on Saturday night after announcing that he would be calling time on his career at the end of the campaign.<br/><br/>Kroos added yet more silverware to his stacked trophy cabinet after Los Blancos' 2-0 win over Borussia Dortmund. Second-half goals from Dani Carvajal and Vinicius Jr saw the veteran midfielder claim his sixth European Cup. <br/><br/><br/>Minutes before the final whistle, Madrid boss Carlo Ancelotti allowed the 34-year-old to have a touching send-off and he left the Wembley pitch to the jubilant applause of the club's supporters. <br/><br/>Kroos reacted in kind, passionately gesturing towards the fans with his arms raised and an enthusiastic fist pumped into the sky. <br/><br/>'It could be worse,' Kroos told CBS Sports when asked how it felt to retire with a Champions League winners medal. 'That was the plan but of course, it's difficult to plan this. <br/><br/>'We didn't play our best match today obviously but it seems like in these games we're unable to lose.<br/><br/>'We were pretty lucky in the first half, we didn't play a good game. We changed some things, we tried to be a bit more compact. [Carlo Ancelotti] moved Jude [Bellingham] next to me to be a little more compact and I think it helped. <br/><br/>'After we scored we improved and then there was no doubt anymore but first half we struggled a lot.'<br/><br/>Kroos has made a mighty 465 appearances for Los Blancos - scoring 28 goals and registering 98 assists - the 17th highest in club history, and second-highest of players still with the club behind team-mate Luka Modric.<br/><br/>Following the announcement of his retirement last month, the club 'expressed gratitude' to Kroos for his tenure and said that the player would 'go down in Real Madrid history as one of our club and international football's greatest legends.'<br/><br/>'Toni Kroos will remain forever in the hearts of every Madridista thanks to his mastery of the game and the fact he has given his all for our jersey, a steady example of the values ​​of Real Madrid,' the statement added.<br/><br/>Real Madrid president Florentino Perez made his tribute, adding: 'Toni Kroos is one of the great players in Real Madrid history and this club will always be his home.'<br/><br/>Kroos has played a key role in Madrid's title-winning success this season, featuring in 32 league matches and registering nine goal contributions.<br/><br/>'You don't lose finals,' Kroos added after Madrid's latest success. 'That's a good base to have. It's crazy when you see our route to the final in recent years. <br/><br/>'It's about quality of course but the mentality is crazy to even be the worst team and win these games. It's a lot of believing and I think that separates this club from all the others.'<br/><br/>His renewed form saw him take up the mantle at international level once again, following his initial retirement in 2021 in the wake of Germany's Euro 2020 campaign.
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Wembley suffered a fresh security fiasco last night after what appeared to be an orchestrated band of pitch invaders delayed the opening moments of the Champions League final. <br/><br/>On the week the Football Association revealed it had pumped £5million into improving Wembley’s security provisions, the UEFA showcase between Real Madrid and Borussia Dortmund was stopped soon after kick-off after at least three fans tried to enter the pitch, two of them successfully.<br/><br/>Borussia Dortmund midfielder Marcel Sabitzer tackled one to the ground. <br/><br/>Following the disgraceful scenes that marred the Euro 2020 final here at the national stadium in the summer of 2021, the FA were determined to host a trouble-free night.<br/><br/>But the governing body's first UEFA showcase final since that fateful night here three years ago was again impacted by an embarrassing security breach.<br/><br/>A record number of stewards for an event at Wembley were deployed for the game - in the region of 2,600.<br/><br/>But even that enough wasn’t to prevent intruders from forcing their way onto the pitch, much to the annoyance of both sets of players and benches.<br/><br/>On the plus side, the supporters’ route into Wembley is understood to have run smoothly, in complete contrast to the previous two finals in Paris and Istanbul which were both impacted by logistical issues outside the stadiums leading to fan chaos outside the respective grounds.<br/><br/>Nevertheless, the chaotic scenes at the start of the game will have come as a blow to Wembley’s security staff.<br/><br/>Cameras switched attention to the crowd rather than the pitch invasion, with viewers initially kept unaware of the disturbance.<br/><br/>More than 600 stewards in yellow bibs lined the touchline as the players came off for half-time.<br/><br/>An investigation was launched into how security at such a high-level match could be breached and whether there was any political element behind the incidents.<br/><br/>The Wembley Stadium announcer warned fans in English, German, and Spanish that entering the pitch was 'an arrestable offense'.<br/><br/>Social media was awash with criticism towards the FA after the early delay as users playfully referenced the £ 5 million expenditure on bolstering Wembley security since Euro 2020. <br/><br/>‘That’s £5million well spent,’ read one post on X, the social media platform formally known as Twitter.<br/><br/>Another read: ‘Well…that’s £5million well spent. What a waste of money.’<br/><br/>Speaking this week, Chris Bryant, the FA’s director of tournaments and events, said: ‘It’s vital we deliver and do everything we can control in the best possible way.<br/><br/>‘We want this event to be as successful as possible for every reason, not least for the fans and the event in itself, but we know a lot of people will think about the Euros final as well.<br/><br/>'A massive amount of work has gone into this, an event of national significance and a chance to show London is fantastic at delivering big events, that Wembley is a home for big football matches and we do events like this very well.’
⏲ 0:58 👁 65K
Ehsaas Telethon - Qurbani Appeal<br/><br/>Fund raising from international community.<br/><br/>Cow Share in Pak || 80$<br/>Goat Share in Pak || 175$<br/>Cow Share in IND || 37$<br/>Goat Share in IND || 160$<br/>Cow Share in JAMMU & KASHMIR || 82$<br/><br/>For Call: 1-718-393-5437<br/>For Donation: 1-855-617-7786<br/>Online: www.ehsaasfoundation.org<br/><br/>Account Name: Ehsaas Foundation <br/>Bank Name: Chase Bank <br/>Account Number: 202535861<br/>Routing: 021000021<br/>SWIFT: CHASUS33<br/><br/>Subscribe Here ➡️ https://www.youtube.com/ARYQtvofficial<br/><br/>#EhsaasTelethon #QurbaniAppeal #ARYQtv
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Fresh calls for the Elizabeth line to be extended into Kent have been made by several London councils, who argue the scheme is “vital to catalysing housing and employment opportunities”.In south-east London, the line currently only extends as far as Abbey Wood - in zone 4 - but a potential route further out into Ebbsfleet and Gravesend in Kent was ‘safeguarded’ by an Act of Parliament back in 2008.
⏲ 0:47 👁 10K
Ehsaas Telethon - Qurbani Appeal<br/><br/>Fund raising from international community.<br/><br/>Cow Share in Pak || 80$<br/>Goat Share in Pak || 175$<br/>Cow Share in IND || 37$<br/>Goat Share in IND || 160$<br/>Cow Share in JAMMU & KASHMIR || 82$<br/><br/>For Call: 1-718-393-5437<br/>For Donation: 1-855-617-7786<br/>Online: www.ehsaasfoundation.org<br/><br/>Account Name: Ehsaas Foundation <br/>Bank Name: Chase Bank <br/>Account Number: 202535861<br/>Routing: 021000021<br/>SWIFT: CHASUS33<br/><br/>Subscribe Here ➡️ https://www.youtube.com/ARYQtvofficial<br/><br/>#EhsaasTelethon #QurbaniAppeal #ARYQtv
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In 1936, when Ethiopia is being invaded by the Italian army, Lieutenant Silvestri sets off for the nearest camp hospital to take care of a toothache. En route he meets a young Ethiopian girl..
⏲ 1:37:27 👁 35K
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